5-Hydroxyeicosatetraenoic acid(5-HETE) is an endogenous eicosanoid.
5-HETE is member of a closely family of eicosanoids that are created by a
large variety of human and other mammalian cell types. 5-HETE is a
product of the cellular metabolism of arachidonic acid by the protein
5-lipoxygenase.
5-HETE is a key intermediate of the arachidonate-dependent protecting communication in monocytes exposed to peroxynitrite. Peroxynitrite induced the nuclear membrane translocation of 5-LO and increased its protein activity via a mechanism sensitive to low concentrations of inhibitors of 5-LO or the 5-LO activating protein, furthermore on genetic depletion of the latter protein. Inhibition of 5-LO activity was invariably related to the cytosolic localization of PKC, the mitochondrial accumulation of unhealthy, and a fast MPT-dependent mortification. of these events were prevented by nanomolar concentrations of the 5-LO product 5-HETE.
5-HETE ELISA Kit( www.cusabio.com/ELISA_Kit-62303/ ) recognizes natural and recombinant Human 5-HETE. No cross-reactivity or interference between Human 5-HETE and analogues was discovered. Limited by existing techniques, cross-reaction should exist, as it is impossible to complete the cross-reactivity detection between Human 5-HETE and the analogues.
5-HETE is a key intermediate of the arachidonate-dependent protecting communication in monocytes exposed to peroxynitrite. Peroxynitrite induced the nuclear membrane translocation of 5-LO and increased its protein activity via a mechanism sensitive to low concentrations of inhibitors of 5-LO or the 5-LO activating protein, furthermore on genetic depletion of the latter protein. Inhibition of 5-LO activity was invariably related to the cytosolic localization of PKC, the mitochondrial accumulation of unhealthy, and a fast MPT-dependent mortification. of these events were prevented by nanomolar concentrations of the 5-LO product 5-HETE.
5-HETE ELISA Kit( www.cusabio.com/ELISA_Kit-62303/ ) recognizes natural and recombinant Human 5-HETE. No cross-reactivity or interference between Human 5-HETE and analogues was discovered. Limited by existing techniques, cross-reaction should exist, as it is impossible to complete the cross-reactivity detection between Human 5-HETE and the analogues.
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