Immunomodulatory Properties of IL-26

An associate professor of biology recently co-authored a research paper that identifies IL-26 is a 171-amino acid protein. IL-26 is expressed in sure herpesvirus-transformed T cells however not in primary excited T cells. IL-26 signals through a receptor complex comprising two distinct proteins called IL-20 receptor 1 and IL-10 receptor 2. By sign through this receptor complicated, IL-26 induces fast phosphorylation of the transcription factors STAT1 and STAT3, that enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule on the surface of animal tissue cells.

IL-26 was detected in many T lymphocyte lines, including human T lymphocyte cancer of the blood virus-transformed cell lines. IL-26 is created by activated memory however not by naive CD4+ T cells, severally of costimulation. IL-26 could influence sure aspects of the response, the foremost operate of IL-26 remains to be outlined. As a primary step in process IL-26 activities, we tend to known a receptor complicated specific for IL-26 and characterised the signal transduction events induced by this protein.

IL-26( www.cusabio.com/ELISA_Kit-84485/ ) was quantified by ELISA. Briefly, 96-well plates were coated with 5 μg/ml polyclonal goat anti-IL-26 Ab. After saturation with PBS containing 2% non-fat powdered milk, plates were in turn incubated with samples or recombinant human IL-26, with a biotinylated polyclonal goat anti-IL-26 Ab and so with streptavidin-HRP. Plates were washed between every steps and sure Abs were disclosed with the TMB substrate. Optical density was measured at λ = 450 nm.