Anti HIV new drug development

In the study, scientists from Australia found that three of the HIV fragmentation - 1 reverse transcriptase inhibitors, can effectively inhibit the activity of HIV - 1 reverse transcriptase, for the prevention and treatment of HIV - 1 drug development provides an important information.

In the study of saturation transfer, the researchers used magnetic resonance imaging (MRI), and in the experimental method of in vitro activity, found the viral fragment 1 reverse transcriptase inhibitors (NNRTI) and reverse transcriptase inhibitors (NRTI) compared to the chemical structure and mechanism of action of the fragment is completely different.

Researchers identified three compounds can inhibit HIV RNA and DNA dependent DNA polymerase activity of reverse transcriptase, in micro friction levels of concentration, but still retains the suppression mutation in the reverse transcriptase enzyme, including three mutations in the NNRTI resistant effect: K103N, Y181C and G190A.These synthetic compounds could inhibit mouse Moloney leukemia virus, retroviral activity, but EC on our production: oli DNA polymerase I Klenow fragment no inhibitory effect.

The researchers also analyzed the dynamic balance, the results showed that one of the fragments is the special effect of HIV - 1 reverse transcriptase inhibitors, on the dNTP substrate, and the other is a compound of a competitive inhibitor, DNA template by the special effects of reverse transcription polymerase activity / primer, and so the compound also inhibits RNA activity of H.In, this dNTP competitive reverse transcriptase inhibitor NRTI M184V.In and other anti viral test activity, the study of the template / primer can inhibit HIV - 1 copies.

To sum up, the study found that 1 of the fragments with a combination of three pieces of screening with anti HIV method - the discovery of HIV prevention and treatment of powerful functions.The fragment 1 reverse transcriptase activity - provides a new opportunity for the development of new drugs has a very important significance.

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