Lab grown tissue

Lab grown tissue may one day provide a new therapy for the joints, including the joints, cartilage, tendons and ligaments.

Cartilage, for example, is the cap bone end, and allows the joint to work smoothly and hard materials. Biomedical engineer, University of California at Davis, explores how to work harder to engineer cartilage, and maintain a strong body of nature, in the journal reports on new progress, this week's proceedings of the National Academy of Sciences.

"Is a problem with the tissue engineering, mechanical properties in far different from natural organization," Ailaifusailiao MAKRIS, a postdoctoral fellow in biomedical engineering at the University of California, Davis, and first author on the said. Makris is Professor A. Athanasiou Kyriacos, a professor of Biomedical Engineering and Department of orthopedics surgery for the outstanding teaching, biomedical engineering, and under the supervision of the.

While the engineered cartilage has not been tested or approved for human use, the current approach to the treatment of severe joint problems is associated with the transplantation of natural cartilage. But it is well known that the method is not sufficient for a long-term clinical solution, Makris.

The main component of the cartilage is a collagen, which also provides the strength and flexibility of the organization, including ligaments, tendons, skin and bones. Collagen is produced by the cells and by the long fiber, which can be cross-linked together.

Engineering new cartilage

The Athanasiou group of researchers has been maintained in the laboratory by native cartilage and cartilage cultured cells, cartilage or, produced by engineered cartilage.

"The cells in the engineered tissue produce the initial immature matrix, and the process of maturation makes it more rigid," Makris said.

Knee joints are usually low in oxygen, so researchers are in the role of natural or engineered cartilage in depriving oxygen. In these two cases, low oxygen leads to more cross-linking and strong materials. They also found that the enzyme called ELISA, which is a test of the enzyme, was triggered by a low oxygen level, and promoted the cross-linking and made it stronger.

"The impact of the work presented in the proceedings of the National Academy of Sciences is a huge relative to the use of tissue grafts in surgery, as well as the use of tissue engineering, the principle of the new organization," Athanasiou said. Plants such as dead bodies, tendons, ligaments, or - the infamous loss of stored mechanical properties - are now in the development of the University of California at Davis, which makes them more powerful, full-featured technology, he said.

Athanasiou is also envisaged that many organizational engineering methods are now being changed to enhance the advantages of technology.

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