Guangzhou hospital clarify ANGPTL7 promote biological amplification mechanism of hematopoietic stem cells

Successfully amplified hematopoietic stem cells can effectively promote hematopoietic stem cell transplantation in clinical applications. Some classes angiogenic proteins, such as angiopoietin-like 7, can improve the hematopoietic stem cell proliferation. However, ANGPTL7 promotion of human hematopoietic stem cells proliferation and activation of downstream signaling pathways of understanding is still not clear.

Study, the experimenters found a can promote human hematopoietic stem cells and progenitor cells in mouse fetal liver cells, the cell-specific expression of Angptl7 protein. In addition, the study also found ANGPLT7 protein can promote Mouse Insulin-like growth factor 1 ELISA Kit http://www.cusabio.com/ELISA_Kit-84017/ and progenitor cells in vivo xenograft host amplification and hematopoietic systems reconstruction. RNA-Seq analysis showed that, ANGPTL7 activation of human hematopoietic stem cells and cells expressing the CXCR4, HOXB4 and WNT downstream targets. In addition, chemical regulation may weaken the role of WNT signaling pathway ANGTPL7 on human hematopoietic stem cells and progenitor cells.

The study found that the secretion of growth factors ANGPTL7 is human hematopoietic stem cells and progenitor cells and hematopoietic reconstitution important regulator of hematopoietic stem cell transplantation has important clinical significance.