A protein that plays a central role in maintaining genomic structural stability

We all know that the double-helix shape allows genetic information to be packed into a molecule of human DNA. But how the complex  information is packed into the cellular nucleus is still unknown to all. The secret of how this crush of genetic code avoids chaos has been revealed recently. An international team has determined that a protein known as lamin A plays a central role in maintaining genomic structural stability after tracking and analyzing the movement of fluorescently-tagged genomic regions within the nuclei of live cells.
The research group was led by Prof. Yuval Garini of Israel's Bar-Ilan University, and with the participation of members of his lab including Dr. Irena Bronshtein-Berger and Dr. Eldad Kepten, then a PhD candidate. They have shown how this protein is involved in the formation of "cross-links" that limit genetic material's freedom of movement within the nucleus. This creates a stable and linked polymeric structure that promotes chromosomal integrity and makes normal cellular replication possible.
In the study, they explain the biophysical underpinnings of chromosome dynamics and organization and provides biophysical underpinnings of chromosome dynamics and organization.
The mechanism discovered by Garini and his colleagues may have significant implications for the understanding and clinical treatment of disease. What's more, it may pave the way to new approaches toward conditions associated with mutations in the lamin A protein.
Their findings were published on August 24th, 2015 in Nature Communications. If you want to know more about the discovery about the protein-based genome-stabilizing mechanism, you can read more online.
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