2015年10月22日星期四
Boys are hopeful to be kept free from Duchenne Muscular Dystrophy
In America, muscular dystrophy affects nearly 250,000 people. It occurs when damaged muscle tissue is replaced with fatty, fibrous, bony tissue and loses function. After years' hard working, scientists have found a way to successfully treat Duchenne Muscular Dystrophy, short for DMD, the most common form of the disease which reatly affects boys. So far, a research group has treated dogs with DMD successfully. The researchers plan to set about human clinical trials in the following years.
DMD is the most common muscle disease among boys, and no effective treatment exist at present. The new discovery can help to develop a wonderful therapy for this desease, according to Dongsheng Duan, the study leader and the Margaret Proctor Mulligan Professor in Medical Research at the MU School of Medicine.
A gene mutation happens on patients with Duchenne muscular dystrophy, which disrupts the production of a protein known as dystrophin. Then a chain reaction that eventually leads to muscle cell degeneration and death will happen due to absence of dystrophin. Later the patients is hard to walk and
breathe like an old man. Besides, dystrophin is one of the largest genes in human body.
The group conducted a study, which shows a common virus can deliver the microgene to all muscles in the body of a diseased dog. When the dogs were 2 to 3 months old and starting to having sign of DMD, they were injected with the virus. They are now 6 to 7 months old and grow up normally.
This virus is a common one and it produces no symptoms in the human body. This virus can yet be regarded as a safe way to spread the dystrophin gene all over our body. It is quite important to treat the disease early before it can do some damage.
Click here to know more about life science:http://www.cusabio.com/Polyclonal-Antibody/UBE2C-Antibody-11098184.html
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