2015年10月26日星期一

New unexpected findings of cell division published

In order to understand more about the mechanisms of cell division, researchers have conducted a series of research using eggs and embryos from frogs and starfish. They unexpectedly found new findings about how animal cells control the forces that shape themselves. The researchers published the paper in the online journal Nature Cell Biology. The study points out that during the process in which a cell divides its cytoplasm to create two daughter cells, which is called cytokinesis, a cell's cortex becomes an excitable medium. We all know that cytokinesis is highly dynamic, but an animal cell has no idea where it will happen before it really happens. The cell has literally ripped itself in two after the things happen. The contractile machinery is quite ephemeral, according to co-author George von Dassow, a University of Oregon biologist at the Oregon Institute of Marine Biology in Charleston. How the cell manages to ensure that the entire surface can participate is not obvious now. However, once specified, only one narrow equatorial band does the crucial act. After chromosomes separate deep in the cell cytoplasm, the surface of the cell immediately enters an excitable state, added von Dassow. During the state, waves of signaling molecules form. They tune in faint signals from deep in the cell to accurately and precisely delineate the working conditions for contractile proteins and other enzymes to assemble at the right place, in the right amount and at the right time during cell division, or during other cell-shape stage. The researchers show in the study that this "cell-cycle-entrained behavior" in the cortex is present in both vertebrates and invertebrates. The dynamic behavior will be clearer combining high-resolution live-cell imaging and mathematical modeling. Related reading:http://www.cusabio.com/Recombinant-Protein/Recombinant-Autographa-californica-nuclear-polyhedrosis-virus-AcMNPV-Viral-cathepsin-11089554.html

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