Stem cells and stem cell niche interaction

Known hematopoietic stem cells from the aorta of the cells, these stem cells circulating in the body, until you find the stem cell niche for hematopoietic ready. Researchers in the transparent zebrafish embryo stem cells marked in green, and then reveals the formation of stem cell niche by time-lapse imaging.

Endothelial cells of the hematopoietic stem cells close to wrapping up, "stem cells to feel this way in the 'den' first step in a happy, like a mother to embrace." At this time of hematopoietic stem cells come into contact with nearby stromal cells or trophoblast, Mouse Cystatin C ELISA Kit http://www.cusabio.com/ELISA_Kit-73147/ can help stem cells maintain adhesion. Seize trophoblast stem cells, like a baby to glue his mother.

Researchers series of confocal microscopy and electron microscopy images, to reproduce this process in zebrafish, and build a complete 3D structure of stem cells, endothelial cells and stromal cells through. "This is the first time in the high-resolution level of stem cells and stem cell niche interaction in vivo imaging," Zon said.

Finally, surrounded with the stem cells begin to divide. They will leave the stem cell niche one, to reach the final of the hematopoietic sites. In mice, the researchers conducted a similar imaging studies found that mammalian hematopoietic stem cells also experienced similar process. In humans, hematopoietic stem cells are bone marrow final home.

Zon, who wants to improve bone marrow transplantation on this basis. They were in a large number of chemical screening in zebrafish embryos and found Lycorinecan promote hematopoietic stem cells and stem cell niche interaction, generate more hematopoietic stem cells.