2015年1月11日星期日

The evolution of life, or rather driven by ribosomal DNA

According to Science Daily reported that since the discovery of how DNA encodes genetic information since most studies on the evolution of life have focused on genes. According to "selfish gene" theory, the presence of cells and organisms just as protective wrap and transfer genes. The new study challenges the theory that if any individual is made "selfish", then it must be the ribosome. This discovery will be the end of all our understanding of the evolution of life, as well as the function of the ribosome itself.

Ribosomes are large and complex molecules in all living cells exist. It contains the genetic information in DNA is transcribed into all the cells can perform most of the work and the mechanism of protein structure of cells. When the organic chemist molecules anthropomorphic, they said elements "want at the lowest energy structure in the form of value." This means that when they have the energy, molecules can be transformed into different configurations, but they still have a possible return state. DNA is still tightly curled state, very difficult to unlock the researchers have not yet fully understand how different molecules unlock and expand it so that replication and transformation.

So the answer Meredith realized that from the perspective of organic chemistry, "DNA What needs" the problem is: it needs to keep curled into a knot. DNA does not want to copy and transformation, so she concluded that DNA is unlikely to be the evolutionary process of dynamic facilitator, so this also raises another question: So in the end is who you want to copy and transformation?

For Meredith and Robert, the answer is obvious: the ribosome. Its rest state is "ready to DNA into proteins." In addition, not only in the ribosome cells in all organisms, they are all living species in almost exactly the same.

Ribosome is composed of two types of molecules: proteins and RNA. RNA is structurally very similar to DNA, which exist in three forms. One form of ribosomal RNA, or said rRNA, textbook knowledge that it is purely structural, composed of ribose "machine" framework or skeleton. Two other RNA, messenger RNA (mRNA) and transfer RNA (tRNA), located outside of the ribosome, which is mainly to help ribosomal "machine" instruction composed of a protein according to DNA. Messenger RNA transcripts of DNA genetic information and pass it to the ribosome. The messenger RNA is transfer RNA information into an amino acid, Mouse Cystatin C ELISA Kit http://www.cusabio.com/ELISA_Kit-73147/ is formed on the ribosome assembly protein.

By the "discovery" of inspiration, Meredith will the selfish gene theory upside down. If the ribosome is "selfish" want to replicate itself? Whether the ribosome will cycle ribosomal RNA interactions with proteins to - to create what we now know of the messenger RNA and transfer RNA-- and secure storage assembly instruction invented DNA? If true, then the ribosomal RNA sequence should match the messenger RNA and transfer RNA, and DNA sequences encoding ribosomal protein phase.

Robert this latest hypothesis was tested, he all the ribosomal RNA and RNA, DNA and protein database of E. coli were compared. If you want to self-replicate ribosomes, ribosomal RNA sample must contain three things people never noticed. First, it must itself genes encoding ribosomal proteins to form a work containing "machine." Second, he must contain messenger RNA needed to pass their genetic information to the "machine." Finally, it must be coded so that the necessary transfer RNA messenger RNA into protein.

Meredith and Robert shows the structure of all the above-mentioned structure of ribosomal RNA in E. coli have a surprisingly good match. "We show traces of ribosomal RNA comprises messenger RNA, transfer RNA and protein structure and function itself encoding the 'gene' is. Ribosome is not just a passive transcribed by the DNA." Robert expressed.

Selfish ribosome model opens in mudflats, marine hydrothermal vents formed during lightning even simple biomolecules last common ancestor common (last universal common ancestor, called LUCA) huge gap between theory. Meredith added: "probably selfish ribosome rendering intimate relationships with other organisms between, we all just different organisms belonging ribosome it."

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