Extend the life of the password, the discovery of new DNA bases

Almost all life on the earth's DNA genetic code is composed of four nucleotides with different bases, they are connected through the arrangement and distorted form a double helix structure.Recently, a team of scientists from the United States found that two new nucleotide with other connection arrangement form a double helix structure, this new discovery can be used for medical USES a new protein synthesis.
Synthetic biologists over the years has been trying to expand the nature of the genetic "letters" sequence.The composition of nucleotide bases cytosine and guanine and adenine and thymine respectively by the letter "C", "G", "A" and "T" said.But so far, the efforts to little effect.For example, some new base pairs but can't form a spiral structure, this limits the possibility of its integrated into the natural DNA structure.Millie m. Georgiadis where the team want to try to see another potential of the letter "Z" (6 - amino - 5 - nitro - 2 - (1 h) pyridone) and "P" (2 - amino - imidazo [1, 2 - a] 1,3,5 triazin - 4 (8 h) one), will form a spiral structure and evolution.
, the researchers found that multiple ZP can form a double helix structure, like CG and AT the same, but also possess a natural DNA needed to complete the biological function of flexible and rigid combination of same.ZP to form the big groove width than the GC to increased 1, in addition with GC is very similar to other properties.ZP were shown, the team also can integrate well with the traditional genome, which owns six DNA "letters" GACTZP can evolve.
These results have a far-reaching influence on synthetic biology, as the standard added two nucleotides of DNA.That create extensions can also be used for DNA polymerase, ligase, kinase and other enzyme reaction.They can also through the platform to create a new function of molecular evolution in vitro, eventually operate in living cells.Perhaps as a "generic" part, nitro can be introduced in multiple sites and shall not affect the geometry of DNA.This makes natural polymerase can effectively search sequence of DNA "letters" of the space.Finally, these results indicate that the conformation of DNA has a natural DNA containing ZP nucleotide plasticity, the plasticity might be in it is very important for the complete biological functions in living cells.
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