Get to know what cytokine recombinant protein is

Cytokine (CK) refers to a class of small molecular proteins which are synthesized and secreted by immune cells (e.g. mononuclear - phagocytic cells, T cells, B cells, NK cells, etc.) and certain non-immune cells (e.g. vascular endothelial cells, epidermal cells, fibroblasts, etc.) via being stimulated and it has a wide range of biological activity. It belongs to recombinant protein with high purity, high activity and low endotoxin features, and it includes recombinant human protein, recombinant mouse protein and recombinant dog protein.

Cytokines can be divided into the following categories by function:

1. Interleukin (IL)

This is a class of cytokines produced by a variety of cells and acts on a variety of cells. It originally got the name because it is produced by white blood cells and plays a role in leukocytes and now it continues to use this name.

2.Interferon (IFN)

It is named because of its ability of interfering with viral replication. It has a very wide range of biological activity and plays an important role in the immune response and immune regulation. It is one of the major pro-inflammatory cytokines. Interferon is divided into: I type (seven kinds, such as IFN-α and IFN-β) and type II (only IFN-Y).

3. Tumor necrosis factor (TNF)

It is named because it can both directly kill tumor cells in vitro and in vivo. There are about 30 members in his family. Its main members include: TNF-α, a single-core factor mainly by monocytes and macrophages; TNF-β, one kind of lymphokines and it is mainly produced by lymphocytes and NK cells produce, and its biological activity is similar to TNF -α.

4. Colony stimulating factor (CSF)

A group of cytokines in vivo and can selectively stimulate hematopoietic progenitor cells to proliferate, differentiate and form a cytokine lineage cell colonies, including macrophages CSF, granulocyte CSF, macrophage / granulocyte CSF and stem cell factor.

5. Growth factor (GF)

A class of cytokines which can mediate different types of cell growth and differentiation. According to their function and different the cellular effects, they are named as transforming growth factor (TGF), nerve growth factor (NGF), epidermal growth factor (EGF), vascular endothelial cell growth factor (VEGF), fibroblast growth factor (FGF) and the like.

6. Chemokine

A class of cytokine family which has different target cells chemotactic effect and can be secreted by certain white blood cells and tissue cells. It is a family of proteins including more than 60 members. Most members contain four conserved cysteine (C). According to its N-terminal cysteine arrangement, it can be divided into four subfamilies: CXC, CC, C and CX3C.

You can visit Cusabio’s website to find more recombinant proteins.