A recent study published in the journal JAMA Cardiology shows that detection of high-sensitivity cardiac troponin I can help to identify or rule out whether a patient with chest pain emergency has suffered from myocardial infarction. Although the current US guidelines haven't recommended the application of high-sensitivity cardiac troponin I testing, the technology can indeed rule out acute myocardial infarction more quickly. The journal also published some other famous studies on the development of different recombinant proteins, such as recombinant human proteins, recombinant dog proteins, recombinant rat proteins and recombinant horse proteins.
Johannes Tobias Neumann from the University Heart Center in Hamburg of Germany and other researchers analyzed three queues (BACC, ADAPT and APACE) and found an optimal troponin I threshold for the diagnosis of NSTEMI. They developed and verified a more accurate method of diagnosis and exclusion of acute myocardial infarction.
First, the researchers used the data of BACC queue and found the optimal threshold 6ng / L and developed a fast approach of diagnosis of acute myocardial infarction. European Society of Cardiology guidelines suggest emergency physician conduct high-sensitivity cardiac troponin I tests after the patient reaches the hospital and three hours later. The results show that using the critical value of troponin diagnostic applications resulting type 1 NSTEMI negative predictive value is 99.8% (95% CI, 98.6-100), only one false-negative findings; negative predictive value of all NSTEMI patients is 99% (95% CI, 97.5-99.7) and four false-negative cases were found.
When using 1 hour diagnostic method to measure levels of cardiac troponin I, the negative predictive value 1 type NSTEM was 99.8% (95% CI, 98.6-100)1 hour later; 3 hours later it came to 100% (95% CI, 98.5- 100). In all NSTEMI patients, 406 cases (39%) of patients can be discharged, among which four patients were false-negative (negative predictive value 99%; 95% CI, 97.5-99.7). The results were very precise and recombinant APP played an important role.
When using threshold troponin diagnosis of myocardial infarction, the positive predictive value of one hour diagnosis of Type 1 NSTEMI I was 82.8% (95% CI, 73.2-90), and 3 hours later it came to 78.6% (95% CI, 69.8- 85.8). In all NSTEMI patients, the positive predictive value of 1 hour 87.1% (95% CI, 79.6-92.6), 3 hours of 84.6% (95% CI, 78-89.9).
The researchers identified the method in ADAPT and APACE queue. In ADAPT queue, 1748 patients received two hours of law verification and 249 cases of NSTEMI were found. Admission negative predictive value was 99.6% (95% CI, 99.1-99.9), and 2 hours later it was 99.7% (95% CI, 99.2-99.4). In the diagnostic process, the positive predictive value was 81.5% (95% CI, 75.3-86.3). APACE queue used a similar method of one hour and three hours. In the queue, negative predictive value on admission was 98.6% (95% CI, 98.6-99.2), and 1 hour later it was 99.2% (95% CI, 98.4-99.2 ) and 99.1% (95% CI, 97.1-99.8) after 3 hours; 1 hour later the positive predictive value was 80.4% (95% CI, 75.1-84.9) and 3 hours later it was 68.8% (95% CI, 59.2- 77.3). Transmembrane protein plays an important role in basic physiological processes, including molecule transport, signal transduction, energy utilization and so on. Cusabio offers recombinant proteins of good quality.
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