Scientists have found the method of wound healing without scars

Researchers have figured out how to make new wounds heal by replacing them with new ones instead of the usual scar tissue method through recombinant dog proteins. Before this, mammals want wound healing without scar is considered impossible.

"In essence, we can manipulate wound healing so it can regenerate the skin instead of scars," says George Cotsarelis, a professor of dermatology at the University of Pennsylvania. "The secret to achieving this goal is to regenerate hair follicle, and then the signal released by hair follicle will promote the regeneration of fat.

Scientists have found that existing myofibroblasts can be transformed into adipocytes, suggesting that when a wound heals, the scar tissue can be transformed into regenerated skin. Scientists previously thought that only fish and amphibians could do that. "These findings suggest that we have an opportunity to influence tissue regeneration rather than waiting for scar formation," said Maksim Plikus of the University of California, Irvine.

Previous research by the team showed that fat cells and hair follicles in regenerated skin developed separately but did not develop independently, and hair follicles were always the first to develop. Researchers suspected that the growth of hair follicles can help the regeneration of fat cells, so they induce hair follicles in mice and laboratory-cultured human skin scar tissue growth. This thing will never happen naturally, because there is no scar tissue inside the hair follicle. They found that once the hair follicle had been formed, it could release the signaling protein, BMP, which in fact turned scar fibroblasts into adipocytes. If hair follicles are induced to grow at the wound healing, the result will be that the post-healing skin is nearly the same as before.

"It is generally believed that myofibroblasts can’t become other types of cells, but our work suggests that we have the ability to influence these cells and that they can effectively and stably transform into adipocytes," Cotsarelis said.

It should be noted that the experiment is only in the proof-of-concept phase, which is effective in mouse and human skin samples, but the effect on the living human remains to be checked. Flarebio provides superior recombinant proteins including recombinant CDH15 at great prices.