To better understand the expression and regulation of SRSF2 in human hepatocellular carcinoma

The international academic journal Cancer Research has just published the latest research progress in an article titled "SRSF2 regulates alternative splicing to drive hepatocellular carcinoma development", and the study was completed by Feng Ying Study Groups from the Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. This study through recombinant horse proteins showed that splicein SRSF2 can promote the development of hepatocellular carcinoma by regulating the selective splicing of tumor-associated genes.

SRSF2 is a member of the classical SR family of proteins that not only regulates alternative splicing of genes, but also activates transcriptional processes. Previous studies in the Feng Ying group showed that the SRSF2 gene was knocked out in the liver, leading to delayed growth, severe liver damage, hepatocellular degeneration and severe hepatocellular fibrosis and indicating that SRSF2 protein plays an important regulatory role in the process of maintaining the liver. However, the expression and regulation of SRSF2 in human hepatocellular carcinoma is still not clear.

Under the guidance of Feng Ying, Dr. Luo Chunling and other samples of 90 pairs of liver cancer by tissue microarray study found that SRSF2 protein in patients with hepatocellular carcinoma samples showed high expression of the trend, and the protein expression and pathological grade of liver cancer and the patient's prognosis showed a significant correlation. The results showed that SRSF2 could promote the growth of hepatocellular carcinoma cells, and the function of SRSF2 was mainly dependent on splicing regulation of many genes downstream. SRSF2 regulates the alternative splicing of target genes GCH1 and STK39, leading to increased expression of splice isoforms that promote hepatocarcinoma cell growth, which is associated with the malignancy of HCC. In splicing mechanism, SRSF2 can enhance the exon access and inhibit the exon access dual function.

This study shows that splicein SRSF2 plays an important role in the development and progression of hepatocellular carcinoma by regulating alternative splicing of genes such as GCH1 and STK39. This work not only contributes to the understanding of the pathogenesis of HCC, but also provides a new target and ideas for diagnosis and treatment. Flarebio provides you with superior recombinant proteins including recombinant Aoc3 at good prices.