2014年9月27日星期六

Function and expression pattern of OTOF

OTOF is present in the brain and the tube-shaped structure, that could be a snail-shaped structure in the receptor that helps method sound. The precise operate of OTOF is unsure, it seems to be essential for traditional hearing. Researchers believe that OTOF play a role in emotional chemical signals from nerve cells that are concerned in hearing. This method relies on the concentration of Ca at intervals the cell. The OTOF has many regions referred to as C2 domains that bind to Ca and use it to act with alternative molecules.


OTOF in human with a sort of nonsyndromic hearing disorder. Human with these mutations have a type of deafness referred to as audile pathology, that happens once sound isn't transmitted properly from the receptor to the brain. Some mutation in OTOF end in the assembly of nonfunctional version of OTOF or stop cells from creating any of this protein. A genetic changes most likely alter the third-dimensional structure of OTOF, that impairs its ability to bind to Ca.


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