The researchers used qualitative and quantitative methods to explore
MUTYH. In the study, MUTYH is a human gene encoding a DNA glycosylase,
MUTYH glycosylase, involved in oxidative DNA damage repair. The enzyme
excises adenine bases from the DNA backbone at sites where adenine is
inappropriately paired with guanine, cytosine, a major oxidatively
damaged DNA lesion. MUTYH is localized to the nucleus and mitochondria.
Mutations result in heritable predisposition to colon and stomach
cancer.
Mutations in the MUTYH cause an autosomal recessive form of familial adenomatous polyposis. Polyps caused by mutated MUTYH do not appear until adulthood and are less numerous than those found in patients with APC gene mutations.
Mutations in MUTYH affect the ability of cells to correct mistakes made during DNA replication. Both copies of the MYH are mutated in individuals who have autosomal recessive familial adenomatous polyposis. Most reported mutations in MUTYH( www.cusabio.com/cusabio-1086635/ ) cause production of a nonfunctional or low functioning glycosylase enzyme. When base excision repair in the cell is compromised, mutations in other genes build up, leading to cell overgrowth and possibly tumor formation. The two most common mutations in Caucasian Europeans are exchanges of amino acids in the enzyme.
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Mutations in the MUTYH cause an autosomal recessive form of familial adenomatous polyposis. Polyps caused by mutated MUTYH do not appear until adulthood and are less numerous than those found in patients with APC gene mutations.
Mutations in MUTYH affect the ability of cells to correct mistakes made during DNA replication. Both copies of the MYH are mutated in individuals who have autosomal recessive familial adenomatous polyposis. Most reported mutations in MUTYH( www.cusabio.com/cusabio-1086635/ ) cause production of a nonfunctional or low functioning glycosylase enzyme. When base excision repair in the cell is compromised, mutations in other genes build up, leading to cell overgrowth and possibly tumor formation. The two most common mutations in Caucasian Europeans are exchanges of amino acids in the enzyme.
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Postal Address:Wuhan Hi-tech Medical Devices Park, Building B11, #818 Gaoxin Road, Donghu Hi-Tech Development Area, Wuhan, Hubei Province 430206, P.R.China
Tel: +86-27-87582341
Fax: +86-27-87196150
Email: cusabio@cusabio.com admin@cusabio.cn
Leave a message here:www.cusabio.com/about1_21.html
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