Metabolic Remodeling in HAP1

The international research team led by the University of Leicester say the finding of HAP1 can bind to the mutant huntingtin protein in proportion to the amount of aminoalkanoic acids present in the glutamine repeat region. The subcellular location of HAP1 closely resembles that of Htt. HAP1 interacts with alternative factors concerned in sac trafficking as well as GABAA receptor, Rho-GEF, and HGS. 

  HAP1 interacts with muHtt in a very polyQ dependent manner. Its localization and doable interacting partners have since been characterized, so elucidating a doable role for this protein in HD pathological process. HAP1 is localized in mitotic spindle of dividing striatal cells, such as endosomes, microtubules and vesicles in the basal neural structure and striatial neurons, where HAP1B is preferentially expressed.  

  The role of HAP1(www.bioabb.com/products/Human-Huntingtin%252dassociated-protein-1%28HAP1%29-ELISA-kit.html) in HD pathological process could involve aberration of cell cycle processes, as high immunostaining of HAP1 throughout the cell cycle has been ascertained. HAP1 can also disrupt endocytosis, as it has been detected on vesicles concerned within the early stages of this method. It's doable that the non-pathogenic activity of HAP1 is living thing trafficking which this is often rattled following its association with mHtt. HAP1 interacts with proteins aside from Htt and it's possible that their perform is altered in HD pathological process. These embody dynactin p150Glued, a living substance dynein accent protein concerned in retrograde transport of organelles, and kinesin-like protein that is another transport-mediation protein.