Novel immune target identified in PGRMC1

Researchers at Imperial College London have identified that PGRMC1 is expressed in the liver and excretory organ in humans with lower expression in the brain, lung, heart, striated muscle and exocrine gland. In rodents, PGRMC1 is found in the liver, lung, excretory organ and brain. PGRMC1 is over-expressed in breast tumors and in neoplastic cell lines from the colon, thyroid, ovary, lung, and cervix. Microarray analyses have detected PGRMC1 expression in colon, respiratory organ and breast tumors.

PGRMC1 expression is iatrogenic by the non-genotoxic matter 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat liver, however this induction is restricted to males. PGRMC1 is expressed in the ovary and endocrine, where its expression is iatrogenic by progestin and through physiological condition. PGRMC1 is expressed in varied regions of the brain, circumventricular organs, ependymal cells of the lateral ventricles, meninges, together with regions well-known to facilitate spinal curvature.

The yeast PGRMC1 homologue is needed for resistance to wreck. PGRMC1 conjointly promotes survival in human cancer cells once treatment with therapy. In distinction, PGRMC1 promotes death in cancer cells once aerophilic injury. PGRMC1 alters many well-known survival sign proteins. The progestin inhibits cell death in immortalized granulosa cells, and this activity needs PGRMC1 and its binding partner, PAIR-BP1. CUSABIO PGRMC1 elisa kit(www.cusabio.com/ELISA_Kit-96135) has high sensitivity and excellent specificity for detection of Mouse PGRMC1. No significant cross-reactivity or interference between PGRMC1 and analogues was observed.