DNA replication solutions

Every time a human cell division, had to copy the six billion DNA bases, one by one is clearly unrealistic. In fact, DNA replication machine will also intervene more than a starting point, carry out the division of labor. DNA replication is one of the most basic cellular processes, it would be of genetic diversity, disease risk and impact of human evolution.

We know that the mutation rate can affect the timing of replication, early late copies of the DNA fragment or more error prone. If the replication timing differences between individuals, then the mutation risk genome will be completely different. The researchers found that replication timing differences cause some people are more prone to certain leukemia. JAK2 gene mutations known to cause this type of cancer, and this mutation carriers tend to a specific genetic polymorphism, but previously it was not clear what the two are linked. McCarroll et al found that the genetic polymorphisms and copy related premature start, which made it easier for JAK2 mutation occurs.

The researchers found that this can be achieved, because they have developed a new way to study Cusa Taq DNA Polymerase http://www.cusabio.com/Tools-enzyme/Cusa-Taq-DNA-Polymerase-1028780.html Previously this type of research is rather cumbersome, require several weeks of cell culture, but also in the special cell sorting instrument, is a costly and time-consuming complex experiments. Copy the start sooner, the more the number of copies of the gene. Researchers on the basis of the copy number for the genome of different individuals to establish a personalized copy timing spectrum. Subsequently, the researchers through Genome-wide association study identified 16 replication timing-related sites, and named for the replication timing of quantitative trait loci (rtQT). Research shows that this diversity is very common.