PRLR is a cytokine receptor family member, associated with breast development, lactation, cell division and proliferation, such as a variety of functions. Before functional studies on the regulation of metabolism PRLR mainly in peripheral tissues. For example PRLR knockout mice after systemic injection of glucose, the blood sugar level is higher than normal mice. This study suggests that PRLR mainly through indirect regulation of islet density, thereby regulating blood sugar levels. Prior studies have found this group an important role in regulating insulin sensitivity in the liver PRLR area.
At present, it has been found in humans PRLR has five subtypes, there are two kinds of rodents. Which is the main function of long lPRLR subtype hypothalamus. IPRLR overexpression and inhibition of expression of adenovirus. Mice were injected by the third ventricle adenovirus found in the hypothalamus overexpression lPRLR can improve insulin sensitivity in liver, while knockout lPRLR hepatic insulin http://www.cusabio.com/ELISA-Kit/Goat-insulin-like-growth-factor-1IGF-1ELISA-Kit-84016.html sensitivity will decrease.
Further study confirmed that regulate glucose metabolism lPRLR peripheral nerve signals pass through the hypothalamus and liver STAT5 signaling pathway of the vagus. Enrich people's understanding of the interaction between the various organs of the regulation of glucose metabolism, helps to strengthen the diabetes and related metabolic diseases pathogenesis understanding.
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