Antibacterial infection target validation study was progression

Olaf Schneewind Research Group, University of Chicago study found that long-term, the biological function of GGT SrtA of Gram-positive bacteria infection is critical, and from a biological point of view is confirmed by SrtA promising candidate antibacterial targets. Young Choi wide task force to carry out synthetic drugs, improve the activity of small molecules and the physical and chemical properties, and through cross vitro biochemical experiments confirmed that the small molecule inhibition of substrate peptides targeting SrtA and turn peptide reactive surface proteins. Olaf Schneewind Task Force will reveal small molecule peptide Mouse RARRES2 ELISA Kit http://www.cusabio.com/ELISA-Kit/Mouse-Retinoic-acid-receptor-responder-protein-2RARRES2-ELISA-kit-99837.html turn inhibitory activity. Shanghai drug researchers then demonstrated on live bacterial mode of action and regulation of biological phenotype of small molecule inhibitors.

Experiments show that this small molecule can better prolong survival of mice infected with a certain healing effect. The researchers further revealed that the small molecule to inhibit the activity of a broad spectrum of Gram-positive bacteria SrtA, and has further developed into a broad-spectrum treatment-positive infections of new types of antibiotics value and potential.

Experts said the study is further targeting other virulence regulatory targets, the development of efficient activity of specific small molecule candidate compounds validate concepts and provides a technology platform.