The possibility of Nogo receptor-1 inhibition of neurite outgrowth verification

Axons glial cell-derived growth inhibitory protein may limit the adult central nervous system functional repair after injury. Nogo protein, myelin-associated glycoprotein, myelin oligodendrocyte glycoprotein and B lymphocyte stimulator, which usually have four kinds inhibitor Nogo receptor-1 receptor neurons interact to inhibit axonal growth .

Professor Kohtaro Takei Yokohama City University confirmed the lateral olfactory tract guidance material (LOTUS) combined NgR1, would prevent four kinds NgR1 ligand binding, thus weakening NgR1 ligand-induced inhibition of neurite outgrowth. LOTUS neurons Recombinant human DCN1-like protein 1  http://www.cusabio.com/Recombinant-Protein/Recombinant-human-DCN1-like-protein-1-11031298.html have the ability to overcome NgR1-mediated inhibition of axonal growth in the future, LOTUS might be to promote effective NgR1 endogenous inhibitor of neuronal regeneration.