E47 protein can reduce the tumor-promoting potential of pancreatic cancer cells

New research confirms that by introducing a protein called E47 can induce pancreatic cancer cells revert to normal cells. DNA sequence-specific binding E47 and control some genes associated with the growth and differentiation.

Sanford - Burnham Medical Research Institute, Dr. development, aging and regeneration projects Visiting Professor Pamela Itkin-Ansari said: "The first time we demonstrate overexpression of a gene can reduce the tumor-promoting potential of pancreatic cancer cells, they will be re-programmed original cell type.

Construction of a kind of human pancreatic ductal adenocarcinoma cell line, E47 than normal levels it produces higher. Increase in cell E47 makes arrest in G0 / G1 growth, differentiation as a return to acinar cell phenotype. In vivo studies show that, when the Recombinant mouse Baculoviral IAP repeat-containing protein 5 http://www.cusabio.com/Recombinant-Protein/Recombinant-mouse-Baculoviral-IAP-repeat-containing-protein-5-11031431.html into the mice, in comparison with untreated cancer cells was significantly decreased ability to form tumors.

Outside the University of California, San Diego Moores Cancer Center, professor, National Cancer Institute, Dr. pancreatic Special Group Co-chair Andrew M. Lowy said: "The current use of cytotoxic drugs are used to treat pancreatic cancer, the average survival time of patients after diagnosis is only is a day for six months, to improve the treatment of calculations. found that we can make these cancer cells to differentiate into a recession is not threatening phenotype encouraging.