Circadian rhythm and virus infection may affect the process of disease

A study suggests that the relation between time of virus infection and circadian rhythm of the host may affect the process of disease. Interfering circadian rhythm of an organism may affect its immune response, but the impact of host circadian rhythms on virus process remains unclear. Thus, researchers in this study decided to use various recombinant proteins such as recombinant mouse proteins to descend into the problem.

Akhilesh Reddy and his colleagues used a herpes virus to infect mice and mice fibroblast cells at different times of a day. When compared with mice infected with the corresponding matt active phase, mice which were corresponding to light phase in the rest period and beginning to expose to these viruses showed a 10-fold virus replication.

Similarly, the time of infection affects virus replication of the fibroblasts cells in mice, suggesting that the cells rhythm clock controls viral process. In addition, interfering the key clock gene Bmal1 can increase the herpes infections of mice and mice fibroblasts and also increase the A influenza virus infection of mice fibroblasts.

Proteomics analysis showed that intracellular protein transport, biosynthesis, protein synthesis and chromatin assembly may affect such rhythm regulation of viral infections. According to the authors, these findings suggest that interfering rhythm cycle may affect the severity of virus infection and may represent a potential tool for the regulation of viral replication in the host.

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