Researchers from School of Biomedical Engineering of Shanghai Jiaotong University and Bio-X Institute conducted the research of epigenetic spectrum of female mouse reproductive stem cells and found the epigenetic regulation mechanism which decides basic biological characteristics of the cells. Related study was recently published online in the journal Genome Biology, which also published a lot of studies about recombinant proteins such as recombinant mouse proteins.
Conventional wisdom holds that the produce of oocytes of vast majority of female mammals occurs only in the fetal period, and the number of oocytes doesn't increase after birth but decreases by years, which means that there are no germline stem cells in ovarian after birth. Do female mammals have germ stem cells? If so, what is the molecular mechanism that decides stem cell characteristics of development unipotency and undifferentiation?
Zhao Xiaodong study group from Shanghai Jiaotong University and Wu Ji study group from Bio-X Institutes Jiaotong University conducted collaboration and discovered female reproductive stem cell-specific histone modifications label of mark enhancer; more importantly, this study reveals DNA methylation determines developmental unipotent of female reproductive cells as a major epigenetic regulatory mechanism by inhibiting the development process of somatic cells. And it also involves in the maintenance of their female gender identity. At the same time, the researchers also found that germ cell-related factor PRMT5 also plays an important role in maintaining undifferentiated state of female reproductive stem cells. Flarebio also provides recombinant proteins such as recombinant Cdh9 at good prices.
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