Chronic stress and anxiety are found to be the potential culprit of liver cancer

Xia Feng research team from Southwest Hospital of Third Military Medical University and Quanjun Hepatobiliary Surgery Institute announced on 27th that through long-term study on autonomic nervous regulation of liver diseases, and through research on recombinant rat proteins, they found that chronic stress and anxiety is the potential culprit of liver cancer.

"Based on ongoing research over the last 20 years, our team has come to realize that the sympathetic nerve has a wide distribution in the liver, which has a significant effect on the pathophysiological processes of the liver," said Xia Feng. For people who have been under long-term stress and anxiety, their sympathetic nervous system will be in a state of continuous excitement. While the latest research of the team has shown that continuous excitement of the sympathetic nervous system of liver will promote adrenal α1A / B subtypes receptor to regulate the activation of Kupffer cells. Then the liver is in the micro-environment of long-term chronic inflammation, which promotes liver cells to transfer to malignant cells and increases incidence of liver cancer.

According to the introduce of research team member Dr. Huanhong Bo, since the beginning of 2011, the project team collected 54 cases of pathological specimens of patients liver cancer, and the analysis showed that patients with high-density liver sympathetic nerve fibers have shorter survival. In nearly 300 cases of cirrhotic rat experimental animal models, the researchers found that after the removal of removing animal abdominal sympathetic fibers, the incidence of experimental animals inducing hepatocellular carcinoma reduced from 100% to 42%. After using drugs to block the sympathetic neurotransmitter receptor, the incidence of induced liver cancer was reduced to 63%.

Xia Feng said that this study reveals a new mechanism of the sympathetic nervous system regulating the occurrence of liver cancer, providing a theoretical basis for clinical diagnosis and treatment of liver cancer. At the same time, there are many ways to relieve stress and relieve chronic stress.

It is reported that this study titled "Sympathetic nervous system promotes hepatocarcinogenesis by modulating inflammation through activation of alpha1-adrenergic receptors of Kupffer cells" has been published in a new international academic journal Brain Behavior and Immunology. Flarebio offers recombinant proteins of good quality such as recombinant ECE1.