A new study published by Hong Kong University of Science and Technology discovered the a new mechanism which causes autism, mental retardation, schizophrenia and other mental disorders, which is helpful for the development of new therapies for these diseases in the future.
A research team led by Professor Zhang Mingjie at Life Sciences of HKUST used recombinant human proteins and found that the human brain is responsible two molecules SynGAP and PSD-95 which are the main components of proteins in "postsynaptic density area" where nerve signals are received. It can be assembled into a network structure, and this structure will form a stable "oil-droplet shape" droplets.
The study also found that defective proteins in the brain of the autism patients would change the composition of "oil-droplet shape" droplets, thereby changing synaptic signaling activity. The researchers said these findings could explain the etiology of autism and help to understand why gene mutations altering the interaction among these proteins will lead to a series of central nervous system diseases which haven't got a method of treatment, thus injecting new inspiration for the development of therapies.
It is understood that other neuropsychiatric disorders include schizophrenia, mental disorders, depression and so on, and they have the same formation mechanism. The research results have been published in the August 25 issue of the scientific journal Cell. Flarebio offers recombinant proteins such as recombinant Cdh10 at competitive prices.
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