The mechanism of gene defect causing to autism in mice experiments

A Japanese research team found the pathogenesis of gene defect leading to autism in mice experiments, which will help to treat autism.

Kyushu University in Japan issued a statement on 8th after a series of studies using recombinant mouse proteins, saying that autism is a common type of developmental disorder mental illness, and its specific pathogenesis has been unclear. Previous studies suggest that it may be caused by fetal neurodevelopmental disorders. In recent years, genetic studies of autism show that chromatin remodeling factor CHD8 is a gene which has the highest rate of mutation. A research team of this school made CHD8 genes of lab mice show the same mutation like human patients and found that mice also showed symptoms similar to the symptoms of human autism such as abnormal exchange, stubbornness, etc.

The study found that CHD8 mutation made a protein called REST in the mice very active. This protein is very important for neural development, and its abnormal activity may lead to hyperactive neurodevelopmental delay.

The team believes that this discovery shows that it may be possible to treat autism by inhibiting protein REST or related methods. The research results have been published in the British journal Nature. Flarebio provides you with recombinant proteins of good quality such as recombinant Cdh9 at good prices.