A group of scientists led by researchers at Stony Brook University conducted experiments using recombinant human proteins and discovered a new mechanism of a bacterial toxin inhibiting inflammation. Their research showed that a toxin in Yersinia - bacteria agent of plague, can target inhibits protein pyrin. Hereditary autoinflammatory disease - Familial Mediterranean Fever (FMF) - is induced by sustained activation of pyrin protein which is caused by gene mutation.
The study was published in the journal Host Cells and Microorganisms, and it can be used to better understand the genetic origins of FMF and to explore new therapies for the treatment of these diseases.
"This finding is very significant because the popularity of Mediterranean-origin people suffering from Familial Mediterranean Fever (FMF) is very high, and the findings may explain the natural selection process behind the disease," Dr. James Bliska from Molecular, genetics and microbiology department of Stony Brook University School of Medicine, the lead author and professor said, "In addition, bacterial toxins would hijack the body kinase and phosphorylate and inhibit pyrin protein. This process can be converted into the process of treatment of FMF."
Hereditary inflammatory diseases brought by FMF usually occur at some time in childhood and would persist throughout adulthood. There are treatments, but no cure. For example, complications such as arthritis and vasculitis can appear long after the onset of inflammation. Thousands of people from different ethnic origins of the Mediterranean, such as Armenians, Italians, Greeks and Arabs, are suffering from FMF. Flarebio provides you with good-quality recombinant proteins such as recombinant ACSL3.
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