Myrrh has good effect on treatment of cancer

Myrrh has been used for hundreds of years, but scientists just begin to explain how myrrh functions. For instance, it has been known that compounds in myrrh called terpenes can interact with opioid receptors in the brain. This explains that myrrh plays the role of painkillers.

Tests on two myrrh oils in combinations with three frankincense oils from South Africa indicates that a combination of B. papyrifera and C. myrrha oils were synergistic in controlling both Pseudomonas aeruginosa, a gram negative bacterium and Cryptococcus neoformans, a fungus.

The anti-inflammatory mechanisms of myrrh are just being worked out as well. Studies from Korea show that, myrrh stops the inflammatory process by inhibiting the production of molecules that promote inflammation. Myrrh turns off the enzymes that produce nitric oxide, prostaglandins, and some inflammatory cytokines when inflammation was stimulated by LPS, a cell wall component of many bacteria called lipopolysaccarhide, also called endotoxin. LPS is related to things like necrotizing enterocolitis and septic shock.

Their later work shows that myrrh does well in controlling inflammation after a rupture of the large bowel. This may because of its ability to stop inflammation induced by the LPS of the gut bacteria and the ability to kill the organisms as well.

What's worthy to be mentioned, it is with cancer that one myrrh component is turning out to be of greater help. There are several species of myrrh trees, and two of them, C. mukul and C. molmol, contain a compound called guggulsterone. While Guggulsterone is not necessarily toxic to cancer cells by itself, it may solve a big problem that currently affects many cancer treatments.

New research shows that guggulsterone (GGS for short) from myrrh can reverse MDR in several types of cancer. The mechanism is just being found. GGS can act as a competitive inhibitor of P-gp, which means that it is pumped out just like the cancer drugs. But the more time P-gp spends pumping out GGS, the less time it is pumping out cancer drug, so it becomes more effective. This is a pharmacokinetic effect, one drug (GSS) has an effect on how another drug (cancer drug) is acted on by the cells, in this case by keep the drug in the cancer cell much longer.

Recent studies show that, in the cases of pancreatic cancer and gall bladder cancer, GGS and the cancer drug gemcitabine works much better than the drug alone. The combination of the two things produces higher levels of apoptosis in cancers.

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