2015年12月29日星期二

The combination of nanotechnology and medicine

Scientists from New York University (NYU) have created a nanoscale robot from DNA fragments that walks on two legs just 10 nm long. In the great breakthrough, what Seeman and colleagues have done is a good example of biomimetics. By using nanotechnology they can imitate some of the biological processes in nature, such as the behavior of DNA, to engineer new methods and even improve them.

Scientists are also DNA-based nanobots target cancer cells. For example, researchers from Harvard Medical School in the US just reported recently in Science how they made an "origami nanorobot" out of DNA to transport a molecular payload. The barrel-shaped nanobot can carry molecules containing instructions that make cells behave in a particular way. During the research, the research team demonstrates how it delivered molecules that trigger cell suicide in leukemia and lymphoma cells.

The projects of Nanobots made from other materials are also in progress. For instance, scientists from Northwestern University used gold to make "nanostars", star-shaped, simple, specialized nanoparticles that can deliver drugs directly to the nuclei of cancer cells. In their recent paper published in the journal ACS Nano, they show how drug-loaded nanostars behave like tiny hitchhikers that after being attracted to an over-expressed protein on the surface of human cervical and ovarian cancer cells, deposit their payload right into the nuclei of those cells.

Finally, the researchers found that make their nanobot a shape of a star can help them overcome a great problem, which is one of the challenges of using nanoparticles to deliver drugs: how to release the drugs precisely. The shape of star helps to concentrate the light pulses used to release the drugs precisely at the points of the star, according to them.

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