A new leap forward the prevention and treatment of fatty liver treatment

Researchers from the Institute of Biomedical Sciences (Barcelona Biomedical Research Institute) and IDIBAPS Biomedical Research Institute published their research using recombinant mouse proteins in the journal Nature Cell Biology. The researchers hope that this discovery will lead to a new leap forward the prevention and treatment of fatty liver treatment. One of the co-leaders of the study, IDIBAPS group leader Dr. Mercedes Fernández, said that it laid a good foundation for subsequent applied sciences.

Fatty liver is caused by depletion of CPEB4 in mice, and no one knows exactly what causes fatty liver, although we do know that people who are obese or overweight, or those with diabetes, high cholesterol or high triglycerides are more likely to suffer from fatty liver. In addition, rapid weight loss and poor eating habits can also lead to fatty liver. However, NAFLD may also occur in some populations without these risk factors.

Dr. Fernández and his colleagues noted that some large genomics studies have found that gene variants that encode CPEB4 are associated with dyslipidemia. In their study, the murine liver of CPEB4 was lowly expressed in the study. They found that with age, mice gradually developed fatty liver. They also found that feeding a high-fat diet to young mice deficient in CPEB4 resulted in a more pronounced fatty liver.

Further studies on the expression of CPEB4 at the molecular level suggest that this protein plays a key role in the liver stress response. For example, placing a liver cell in a stressful state caused by a high-fat diet can disturb the balance of a cell component called endoplasmic reticulum (ER). When lacking for CPEB4, ER shows less response on the stress. ER has many functions, including the production of protein and lipid and the removal of excess waste.

The researchers found that ER regains its balance by releasing CPEB4 to adapt to stress - for example, removing excess waste. They also found that circadian rhythms affected the release of CPEB4; it was more active during the day (the liver had a lot of work to do) and was quietest at night. The team believes that without CPEB4, ER can not fully restore the balance of stress, which will lead to fat accumulation, forming fatty liver. Flarebio offers high-quality recombinant proteins like recombinant TLR2 for your research.