Methylation deficiencies can be important causes of cancer

Every human cell contains a complete DNA gene that contains not only the genetic information of the human body, and the so-called methyl group in the gene is an essential component of human tissue. Researchers at the Jena Institute of Aging in Germany have confirmed for the first time that DNA errors and methylation deficiencies are an important cause of cancer. The results of the study were published in the latest issue of Nature which also publishes other studies on recombinant rat proteins.

Each tissue of the human body consists of tissue-specific cells of a particular attribute. Gene selection is very strict, such as in the intestinal cells only the corresponding gene directory activation into intestinal cells. What plays an important role in gene regulation is the so-called methyl group, which activates the gene by the action of the enzyme, and the process is called DNA methylation. When the human body develops cancer or suffer from aging diseases, the activity of normal gene fragments will be wrong. The exact process and the role of DNA methylation have not been fully studied.

The function of DNA methylation as a gene to start the "switch" (promoter) has been known, but why a single gene has methyl groups (the so-called gene body) is unclear so far. The team led by Francis Nari at the Leibniz Institute for Human Aging for the first time confirmed that the gene would go wrong when the promoter in the gene contained methyl groups. The result is the generation of abnormal proteins that interfere with the composition of normal cells, causing cell function and identity to undergo large-scale destruction, cell variation and may lead to cancer, which is a mysterious process of DNA methylation.

"The results of this study are exciting because we are now finally able to understand why many of the DNA in cancer cells is rarely methylated," Dr. Francis Nari says in a research note. "It is a lack of genes that cause the gene to be abnormal active state, producing abnormal proteins and spreading cancer cells." Unlike the natural degeneration in the DNA life cycle, changes in DNA methylation deletions can in principle be regulated by so-called chemical messenger substances. Dr. Francis Nari added, "There is no DNA methylation in the genome, and there may be a protein mutation, which is a completely new understanding and will provide a new way to treat cancer. If we find a way to make a methyl group transfer to the exposed cancer cell DNA sequence, it is possible to prevent cancer cells from breeding." Flarebio provides you with superior recombinant proteins like recombinant TLR2 at good prices.