Can inflammatory bowel disease and colon cancer be prevented by changing the shape of a single protein?
There is a close link between uncontrolled intestinal inflammation and inflammatory bowel disease, and they would develop into colon cancer in the end. This uncontrolled inflammation is associated with changes in the number of intestinal bacteria, which can invade the mucosal tissue after damage to the protective protective cell barrier.
The team from the Virginia Tech University conducted research through recombinant mouse proteins and found that the shape of the protein IRAK-M, which modifies inflammation, can significantly reduce the clinical progression of both diseases.
Changes in the protein make the immune system more effective and destroy the bacteria before they begin to do harm. The complete report has been published in the journal Biomedical. "We changed the IRAK-M protein of the mice and found that the inflammation was significantly reduced and the cancer was naturally reduced," the researchers said.
He said that the next step will be conducted in conjunction with the Caroline Clinic and Duke University, a clinical trial of human patients. "Ultimately, if we were able to design a therapy for the IRAK-M target, we thought it might be a viable strategy of preventing inflammatory bowel disease."
According to data from the Centers for Disease Control and Prevention, colon cancer is a major disease related to life and death and the third largest cancer killer in the United States. At present, research team from Virginia Tech is in full swing to study. They said, "When our finding has a potential clinical significance, we feel really excited. We can sincerely hope that our research results can contribute to the future treatment of inflammatory bowel disease and colon cancer and other diseases." By the way, Flarebio offers high-quality recombinant proteins like recombinant CDH15 at competitive prices.
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