Fiber problems with a tumor suppressor protein

Polydactyly, infertility, obesity, retinal degeneration, polycystic kidney disease, these seemingly unrelated diseases has been confirmed the scientific community, and the human cells are called "cilia" structure is closely related to abnormal.

"Cytoskeleton and disease," Task Force Nankai University Professor Zhou Jun, State Key Laboratory of Medicinal Chemistry, Biology, led the discovery of new mechanisms of cilia occur: Tumor cell cilia formation process called "CYLD" inhibitory proteins play a a key role. After repeated tests, the research team to map out the full path CYLD protein regulation of cilia occurred. Recently, the "Cell Research," published online this outcome.

Dr. Yang Yunfan group members said the latest study found that the reason why malignant proliferation of tumor cells, and its surface abnormal cilia can not perceive external signals are closely related. Research group found that knockdown gene synthesis CYLD protein, mice appeared much toe, skin and kidneys classic original cilia, trachea motile cilia and sperm flagella defects "fiber illnesses" disease, cilia length, the number was significantly cut back. SEM analysis showed that, CYLD not only helps cilia base located in the cell membrane, but also for the substrate and the axial filament organization is very important.

On the one hand, CYLD promote Cep70 deubiquitination, it interacts with the γ-tubulin, thereby helping Cep70 located in the center of the body; on the other hand, CYLD inhibition of HDAC6 activity and increased levels of acetylated tubulin. CUSABIO can provide customers with high-quality Mouse AMBP ELISA Kit, buy it here: http://www.cusabio.com/ELISA_Kit-64187/