Longevity gene SIRT1 uncover the secret of eternal youth

Research team Shin-ichiro Imai professor at Washington University School of Medicine, led the show, SIRT1 activation of neural activity in specific regions of the hypothalamus to induce skeletal muscle dramatic physical changes and prolong life. Research published in the journal Cell Metabolism.

Professor Shin-ichiro Imai said the skeletal structure of the brain SIRT1 gene expression in aged mice and young mice are similar to 21-month-old mice (equivalent to 70 human years) looks like a 5-month-old mice as active. Previous studies show that the control diet, a low intake of calories can prolong life. But SIRT1 play in the aging process, an important role in the specific mechanism is not clear. Therefore, Shin-ichiro Imai professor team decided to study this.

Researchers designed a two transgenic mice overexpressing can SIRT1 protein: a mouse in body tissues overexpressed SIRT1 protein, while the other group only in the brain of mice overexpressing SIRT1 protein.

Control their diet study found that only brain overexpression SIRT1 ( Human islet cell antibody ELISA Kit http://www.cusabio.com/ELISA_Kit-114618/ ) transgenic mice, although diet freedom, but has shown to delay aging and life extension and other signs, these signs are just like normal mice when feeding structure shown.