Japanese scientists use iPS cells to repair muscular dystrophy gene

Japanese researchers in the United States the latest edition of "Stem Cell Report," the author says, they use induced pluripotent stem cells, successfully repaired the trigger genes that cause muscular dystrophy. This achievement is expected to facilitate the development of a method to improve the symptoms of muscular dystrophy.

Muscular dystrophy is a genetic damage to human muscle diseases, because the body can not produce supporting muscle protein structure, the patient becomes unable to sports, there is almost no effective treatment.

Muscular dystrophy is a common form of muscular dystrophy. The disease due to genetic mutation, leading to maintain muscle structure essential in the synthesis of dystrophin stops midway, and the incidence of abnormal proteins. Occur in patients with decreased muscle strength and muscle atrophy symptoms. Human epidermal growth factor receptor ELISA Kit  http://www.cusabio.com/html/product/CSB-E12124h.html is difficult to aim only causative gene without harming other genes.

Because iPS cells can be reproduced in vitro symptoms of the disease, researchers at Kyoto University in Japan were collected from patients with muscular dystrophy skin cells, iPS cells were cultured. By identifying the genetic structure of the research team, successfully repaired iPS cell disease genes, and genes other than the target gene are no major damage and change. Until iPS cells develop into muscle cells, appeared intracellular dystrophin.

The researchers believe that this kind of normal muscle cells transplanted into the body of muscular dystrophy patients, it may improve symptoms. Next, they will continue to study how to repair a good iPS cells develop into muscle cells transplanted into the patient.