New discoveries help develop more safe and effective drug

GPCRs are the largest and most important human receptor protein family. GPCRs in almost all biological processes, and most of the diseases, including neuropsychiatric disorders, cardiovascular disease, obesity, diabetes, inflammation and cancer in both play a role. Almost half of current drug use GPCRs are to achieve a therapeutic effect.

The new study investigated the mechanism of action of GPCRs at the molecular level, reveals some important knowledge about how drug-related treatment on this receptor family interaction.

Professor Arthur Christopoulos from Monash University, Australia, Rat Insulin-like growth factor 1 ELISA Kit http://www.cusabio.com/ELISA_Kit-84020/ said he hoped this study will contribute to create a more targeted, less side effects of the drug.

"We've solved this research study a new class of drug molecules over time, and how to combine and alter the structure of GPCR proteins in order to achieve the secret of its unique molecular effects," said Professor Christopoulos said.

"This kind of study can explain the behavior of the drug at the molecular level, and to promote the structural basis of the design of a more targeted new drug."

One starts with a known GPCR crystal structure as a template, the research team used computer simulations to map out how and receptor are able to "find" each other different drugs, and when they interact is how to change their shape and direction. Importantly, some predictions generated by computer simulation, both through new biological experiments as well as through the rational design of more effective targeting GPCR molecules has been verified.