The essential role of senescent cells

Cells under certain pressure conditions will forever lose the ability to divide, a process known as cellular senescence. Cellular senescence bad reputation, although it can prevent precancerous cells, thereby inhibiting the growth of cancer, but it is also considered an important driving force of human aging. Over time accumulate senescent cells, will continue to release a series of inflammatory cytokines, chemokines, growth factors and proteases, build organizational environment in many diseases, such as arthritis, atherosclerosis and the elderly cancer.

Buck Institute Judith Campisi and Marco Demaria found cellular senescence in fact be beneficial in wound repair process, they identified senescent cells secrete factors promoting wound repair. The study was published recently in the journal Developmental Cell.

Now many researchers try to remove senescent cells, prevent the development of age-related diseases. And this study has important significance for them. The researchers constructed two different mouse models, one can observe in vivo and removal of senescent cells, there are two other key mutations blocking the senescence program. The researchers found that Human anti-hepatitis B virus e antibody ELISA Kit http://www.cusabio.com/ELISA_Kit-114473/ in the collagen-producing cells and vascular wall cells. These senescent cells secrete PDGF-AA to accelerate wound closure, PDGF-AA is a growth factor present in the platelet.

In blocking the aging process in mice, wound closure is greatly delayed. Researchers recombinant PDGF-AA introduction of these mice, these mice wound repair back to normal.

Studies have shown that in the process of tissue repair aging cells appear shorter, and in aging or chronic tissue senescent cells persist. In addition, in vitro cultured cells to induce senescence, PDGF-AA activation occurs at a very early period. This shows that the senescent cells beneficial or harmful, may depend on time-dependent regulation of secretion. This study suggests that in addition to preventing cancer, cellular senescence may assume more beneficial role in human life.