Scientists influenza vaccine skin patch

Darrell Irvine, Paula Hammond et al found that the micro-needle combination with a polyelectrolyte multilayer technology, can enhance the effect of DNA vaccine delivery. This is achieved with the use of biological agents joint delivery of DNA to achieve the same effect, can increase the intake of cell nucleic acids. This "patch" of the polymer micro-needle is used on the skin, the vaccine will be loaded biodegradable polyelectrolyte film implanted skin surface. Contact with the skin layer of the polymer is dissolved will occur in the application process, so that the micro needle can be removed quickly and easily. Implanted film is released DNA and immunostimulatory RNA into the skin, the duration of the release process is adjustable from a few days to several weeks.

Such multi-layer technique using micro needles triggered immune responses can greatly exceed the direct injection of DNA vaccine. In addition, such a patch containing micro needles can be stored for several weeks at room temperature dry environment without loss of activity. Because it does not require refrigeration technology and Monkey Insulin ELISA Kit http://www.cusabio.com/ELISA_Kit-84817/ embedded biological agents can remain active for a long time, therefore, the vaccine is very suitable for worldwide patch delivery.