Reveals the roots of acute myeloid leukemia

In the small part of cancer patients, the treatment is intended to cure diseases in turn lead to a form of leukemia, a poor prognosis. The traditional view that a series of chemotherapy and radiotherapy-induced genetic mutations can kill harmful cancer cells while stimulating careless acute myeloid leukemia (AML) formation.

Now a new study from the University of Washington School of Medicine, challenged the treatment of cancer is the direct cause of treatment-related AML in this view.

Studies have shown that cancer diagnosed years ago with individuals age, number of hematopoietic stem cells accumulate mutations in P53. When the formation of the cancer, the mutant cells are more resistant to treatment, and after exposure to Mouse glutamic acid decarboxylase autoantibody IgM ELISA Kit http://www.cusabio.com/ELISA_Kit-114807/ accelerated proliferation, which subsequently led to the AML.

Published in the December 8 "Nature" (Nature) magazine these findings for predicting which patients have a risk of developing treatment-related AML, and find some way to avoid the formation of AML has opened up new avenues of research.

In the United States each year, about 18,000 confirmed cases of AML, about two thousand of cases are due to past exposure to chemotherapy or radiation induced (Further reading: Nature released a major discovery of cancer drug resistance mechanisms). Even given active treatment, therapy-related AML is almost always fatal.

Senior author of the paper, director of the Genome Institute at Washington University Richard K. Wilson, said: "This is in contrast with doctors and scientists have long accepted the fact that it allows us to propose a new hypothesis: In patients with therapy-related AML diagnosed long before as part of the aging process P53 random mutation accumulation in some hematopoietic stem cells.