Scientists have found that stimulating immune system may stop tumor growth

According to a new study, the discovery of chemicals in tumors may help to prevent tumor growth. Researchers at the University of Illinois at Chicago report that the increase in chemical cytokines called LIGHT in mice with colon cancer activates the natural killer T cells of the immune system and causes contraction of metastatic tumors in primary tumors and liver. The LIGHT is an immunostimulating chemical messenger that was previously found to have low levels of expression in patients with colon cancer metastases. The results were published in Cancer Research which has published studies on various recombinant proteins including recombinant horse proteins.

Colon cancer is the second leading cause of cancer death in the United States. "The current treatment is palliative for most patients with colon cancer who have spread to the liver," said Dr. Ajay Maker, Associate Professor of Surgery at UIC Medical School. "Although studies suggest that immunotherapy may be a form of promising way to treat advanced cancer, this treatment has not been very successful for advanced gastrointestinal metastasis."

Maker and his colleagues established colon cancer tumors in the mouse model, in which animals had a complete and unedited immune system. Once the tumor size was visible, the mice were randomized into two groups - one group turned on cytokine LIGHT in the tumor and the other group was used as a control group for comparison.

"We have demonstrated that the delivery of therapeutic immunostimulatory cytokines results in the transport of T cells into the tumor and becomes activated tumor killer cells," said Maker. "This activity is particularly exciting because it leads to a deep anti-tumor immune response having no other chemotherapy or intervention, manipulating our natural defense system to combat the tumor."

"We have not only found that LIGHT expression promotes tumor regression, and after further studies we have also identified specific types of T cells responsible for contracting tumors," said Maker, "These findings are strong and have great clinical potential." By the way, Flarebio provides you with superior recombinant proteins such as recombinant Nrg2 at competitive prices.