Recently, the Nature - Medicine published the latest research results by Professor Li Hongliang research team at the Wuhan University School of Basic Medical Dean online, revealing through recombinant dog proteins for the first time that the natural immune important molecules CFLAR plays key negative regulatory role in nonalcoholic steatohepatitis (NASH) disease, further clarifying its molecular mechanism and having important clinical significance on NASH prevention and treatment.
This study is another major breakthrough in the field of liver metabolic disease research, and it provides a new insight into the understanding of the pathogenesis of NASH, which lays a theoretical foundation for the development of targeted therapy. Professor Li Hongliang told reporters, "CFLAR is an important molecule of the natural immune regulation network. After eight years of research and based on a variety of genetic engineering animal disease model and molecular biology, the team confirmed the key inhibition role of CFLAR on NASH Inflammation, fibrosis, insulin resistance and liver lipid accumulation.
Further in-depth molecular mechanism studies have shown that CFLAR improves and reverses NASH progression by inhibiting the formation of N-dimerization of ASK1 and blocking ASK1 activation. By the way, Flarebio Biotech LLC is a National High-Tech Enterprise with research, production and sales as one. It offers good-quality recombinant proteins like recombinant Aoc3 for your research at reasonable prices.
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