A certain protein may be the starting factor for Alzheimer's disease

Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis all are likely to be related to structural collapse of the accumulation of proteins and brain inflammatory response. However, although there are many studies on recombinant rat proteins, the specific causes and mechanisms are unclear.

Researchers at the University of Louisville School of Medicine have found that proteins produced by intestinal bacteria can cause structural protein folding errors in the brain and inflammation of the brain. Their study found that intestinal bacteria can produce a protein has structure similar to the brain protein, and this protein will lead to an increase in the number of α-synuclein in the brain. In the brains of patients with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, structural abnormalities of alpha-synuclein and associated amyloid accumulation can be found.

α-Synuclein is a protein existing in the brain of normal humans. In the brain of patients with Alzheimer's disease and Parkinson's disease, the protein will accumulate and form amyloid substances, thereby impairing brain function. Experts suspected that intestinal bacteria can produce a protein which can bring structural folding abnormalities of proteins in brain, and those brain proteins with abnormal structure will deposite in the brain. In addition, experts also suspected that the protein secreted by intestinal bacteria will promote the inflammatory response of brain.

A study implanted E. coli which can produce this protein in the intestine of experimental mice, while the other group of control mice was implanted with E. coli that could not produce the protein. The results showed that the experimental group mice brain produced more α-synuclein, and the brain inflammation was also stronger than the control group. There was a similar study on nematode also showed a similar result.

The expert said, "These two similar studies on different animals suggest that certain protein secreted by enteric bacilli may be the starting factor for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Understanding this is very important, because many of these factors are not genetically determined. While coliform bacteria are part of our body, and we have many possible ways to influence the number of these bacteria, thereby treating the disease.

Colorectal bacteria play an important role in age-related brain degenerative diseases. Finally, experts said, "We are continuing our efforts to explore this mechanism, thus exploring further possible therapies." Flarebio offers good-quality recombinant proteins like recombinant CDH12 at competitive prices.