The Nobel Prize in Physiology or Medicine in 2016 was awarded to Yoshinori Ohsumi who is interested in recombinant human proteins, because he discovered the autophagy mechanism. This is an evolutionarily conserved process in which eukaryotic cells can be partly recirculated through transporting double membrane vesicle to lysosome. Unlike other mechanisms of cellular degeneration, autophagy can remove aged or damaged proteins, macromolecular complexes and organelles, leaving place for participation in new physiological processes. In addition, autophagy is also a key cellular process for the removal of invading microbes and toxic protein aggregates, which plays a key role in the fight against infection, aging, and many human diseases.
Although autophagy has been confirmed in the 1960s, scientists still have little knowledge of its mechanisms and physiological significance over the next few decades. The work of Yoshinori Ohsumi significantly changes the understanding of this important cellular process.
In 1993, Yoshinori Ohsumi published his groundbreaking in fifteen genes in the yeast. Subsequently, he cloned these genes in yeast and mammalian cells and elucidated the function of the coded protein. Based on the pioneering discovery of Yoshinori Ohsumi, the importance of autophagy in human physiology and diseases is now widely recognized. Flarebio offers recombinant proteins of good quality such as recombinant Nrg2.
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