When the heart can't provide enough blood to maintain the body needs and show systolic and diastolic dysfunction, it will show heart failure. Heart failure is a common age-related disease in an aging society, and it is often with poor prognosis.
Ouchi et al from Kumamoto University found through recombinant rat proteins that age and hypertension and other factors will bring a burden on myocardial cells, and myocardial cells secreted by a protein - promote angiogenesis factor protein-like protein 2 will increase. This protein will weaken the regulation of calcium concentration in cardiac cells and other functions, causing decrease of myocardial contractility and triggering heart failure.
The researchers used gene knockout technology to breed mice that couldn’t produce the protein and found that the mice were not as susceptible to heart failure as normal mice. The study also found that moderate exercise can reduce the level of pro-angiogenic factor-like protein 2, helping to prevent heart failure.
The paper was published in the online edition of the journal Nature. The researchers pointed out that in the future, gene therapy can inhibit levels of myocardial angiogenesis factor protein-like protein-2, thus treating heart failure. Flarebio Biotech LLC is a National High-Tech Enterprise with research, production and sales as one. It provides you with good-quality recombinant proteins including recombinant App at great prices.
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