Researchers successfully conduct mice experiment to cure autism

A team composed of Prof. Fukuda Mishi and Prof. Liu Mao from the Department of Life Science, Tokyo Pharmaceutical University successfully discovered through recombinant rat proteins that a new-type protein CAMDI in a study which can bind to DISC1. It was confirmed by other research teams that the CAMD1 gene is likely to be the genetic risk genes which lead to serious mental illness. CAMD1 mutation and psychiatric disorders are associated with abnormal behavior.

Researchers produced CAMDI gene-defected mice in advance and analyzed them. They found that the cortical neuron cells of this mouse showed slow movement, and this phenomenon is also one of the main causes of developmental disorders. Behavioral observation of mice showed that they were hyperactive, repetitive movements and unable to adapt to the new environment and lacked for social and other typical autistic behavior. In addition, the researchers also found that CAMD1 can control enzyme activity of deacetylase inhibitor HDAC6. CAMDI gene defect can cause HDAC6 abnormal activity, which directly results of regulation of nerve cell migration center immature, and nerve cell migration becomes slow.

In further study, the team members conducted HDAC6 inhibitor administration to the fetal brain cells cerebral cortex at the motor phase. Follow-up observation can be found in these mice that nerve cell recovery returned to normal, and hyperactivity, repetition, and the ability to adapt to new environments and other issues have been restored.

In the HDAC6 enzyme activity inhibitor, there is a skin T cell lymphoma treatment drug called "SAHA (alias: Vorinostat)" has been widely recognized in drug repositioning (Drug repositioning) and is expected to be used as a therapeutic agent for mental disorders. The researchers said they will explore the SAHA application trials and strive to develop new therapies. The details of this study have been published in EMBO, the official journal of the European Molecular Biology Organization. Flarebio provides good-quality recombinant proteins such as recombinant Cdh9 at great prices.