c-tau protein levels in people with early-onset psychosis are higher than healthy people

A study published in the International Early Psychosis Association (IEPA) in Milan, Italy, showed that c-tau protein levels in people with early-onset psychosis (onset earlier than 18 years) are significantly higher than those of healthy people. The conclusion was reached through a series of research using recombinant rat proteins.

Early onset psychosis (EOP), including early onset of schizophrenia (EOS) and emotional non-schizophrenia mental disorders, is a severe mental illness with the onset time before the age of 18, and the cause of EOP is not currently clear. Previous studies have shown that these patients often have severe neurological loss, such as inattention, lack of executive capacity and memory loss. The researchers believe that these symptoms show neurocognitive loss of the patients.

In diseases related to the loss of neurocognitive ability, such as Alzheimer's disease, deterioration is often associated with increased levels of neurodegenerative biomarkers such as tau proteins in blood and cerebrospinal fluid. In this study, the researchers analyzed plasma tau levels (including tau total protein [t-tau] and ruptured tau protein [c-tau] in EOP patients, these marks are related to dementia and trauma brain injury.)

The researchers analyzed plasma t-tau and c-tau levels in 20 patients and the control group (n = 20). The results showed a significant increase in c-tau levels in patients with an average of 2150 pg / ml in EOP compared to an average of 1100 pg / ml in the control group.

"This study shows that tau protein metabolism may affect EOP," the researchers conclude, "This study provides new insights into the pathogenesis of EOP as well as new therapeutic strategies." Flarebio offers good recombinant proteins such as recombinant CDH12 at competitive prices.