A new immunotherapy technology that can completely reverse allergic reaction in mice

In the best of cases, food allergy can only be frustrating; while in the worst case, food allergy can be life-threatening. Recently, however, scientists have developed a new immunotherapy technology that can completely reverse the allergic reaction in mice and the research used a lot of recombinant proteins including recombinant rat proteins. They believe that this technology can also be used for the treatment of human allergies. This treatment technique works by triggering the body to produce new dendritic cells that can tell other immune systems to stop the excessive immune response. This ensures that the quickest and most severe types of allergic reactions will not occur.

"If we can use this new therapy to reliably treat food allergies or related diseases such as asthma or autoimmune diseases (such as multiple sclerosis)," says John Gordon, a scientist at the University of Saskatchewan in Canada, then it will change the lives of many affected people."

Dendritic cells are naturally generated in tissues exposed to the environment, such as the lining of the skin or nasal cavity, lungs, stomach and intestine. Gordon and his team extracted the cells from mice and exposed them to a specific mixture of proteins, a naturally occurring vitamin A-related acid in the human digestive system, and an allergen (peanut or egg white).

When these modified dendritic cells were re-implanted in mice, the allergic reaction in mice almost disappeared, and the sensitive immune cells activated by allergic substances have been like in healthy and non-allergic the human body. Although the technology has currently been tested only in mice, the researchers hoped to be able to carry out human trials next year. "We have a lot of people with allergies who are willing to give their cells to us for testing," Gordon said.

The effective treatment of allergies can change the lives of millions of people. In the United States alone, there are an estimated 15 million food allergy sufferers, and one in 13 children suffers from some kind of allergy. The team believes the study could also be used for other diseases associated with the immune system such as multiple sclerosis (MS). Gordon explained that only a few changes can be applied to the treatment of autoimmune diseases.

The study was published in the Journal of Allergy and Clinical Immunology. Flarebio provides you with superior recombinant proteins including recombinant CDH2.